Rectal absorption of diazepam in epileptic children.
نویسندگان
چکیده
منابع مشابه
Rectal absorption of diazepam in epileptic children.
The absorption of diazepam after rectal administration was studied in children with epilepsy. When given as a solution, diazepam was rapidly absorbed and produced serum diazepam concentrations above 200 ng/ml within 10 minutes in most children. However, a commercial suppository formulation was absorbed slowly and cannot be recommended for urgent treatment of fits. There is a need in the UK for ...
متن کاملComparison between rectal administration of diazepam in solution and intravenous administration for management of convulsive disorders in infants and children
In order to compare rectal and intravenous(IV) administration of diazepam for management of convulsions,a prospective cross-sectional case-control study was conducted on 94 convulsive infants and children referring to the Emergency department of the university hospital No.1 in Kerman.all children were randomly divided into two groups.the patients were matched with regard to the cause,type,durat...
متن کاملEffects of the rectal administration of diazepam. Diazepam concentrations in children undergoing general anaesthesia.
Diazepam 1 mg/kg body weight was administered rectally to 14 children (11-22.5 kg) before minor surgery under general anaesthesia. Administration in solution (n = 7) resulted in a rapid increase in serum concentrations which were maintained for 8 h. Administration by suppository (n = 7) resulted in significantly lower serum concentrations at 10 and 20 min, but higher concentrations at 2 h. At o...
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15 صفحه اولEfficacy and Risk of Respiratory Depression with Rectal Diazepam Use in Children with Epilepsy
Rationale: Rectal diazepam (0.5 mg/kg-maximum single dose 20 mg) is our standard practice for terminating prolonged (seizure > 5 minutes and continuing) or acute repetitive seizures in children, both inpatient and at home. Recently, clinically significant respiratory depression, requiring mechanical support has been reported in 8.8% of children receiving rectal diazepam (Norris et al, Dev. Med....
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 1982
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.57.4.264